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. 2024 Jul 30;14:17515. doi: 10.1038/s41598-024-67371-5

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© The Author(s) 2024

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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Inhibition of ex vivo IL-23–stimulated IL-17A production in rat whole blood following oral dosing with JNJ-77242113. IL-17A levels produced in whole blood samples (diluted 5 × in media) after addition of 4 ng/mL IL-1β were subtracted from IL-17A levels produced with 20 ng/mL IL-23 and 4 ng/mL IL-1β. Doses below 1 mg/kg (not shown; 0.03, 0.1, and 0.3 mg/kg) showed no significant difference from vehicle control. Bars represent medians and error bars denote interquartile ranges. Data from 5 experiments were combined. Plasma samples from each animal were analyzed using an LC–MS/MS method and dilution adjusted to report concentrations of JNJ-77242113 in the assay. IL interleukin, LC–MS/MS liquid chromatography tandem mass spectrophotometry, ns not significant, PO orally. *P < 0.05, ****P < 0.0001.