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. 2024 Jul 30;14:17515. doi: 10.1038/s41598-024-67371-5

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© The Author(s) 2024

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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In a rat skin inflammation model, oral JNJ-77242113 showed systemic pharmacodynamic activity. Inhibition of IL-23 stimulated (A) IL-17A, (B) IL-17F, and (C) IL-22 expression in rat skin. (D) Change in ear thickness (Day 4–Day 0) was ameliorated by oral pretreatment with JNJ-77242113. Boxes show medians and interquartile ranges and error bars denote minima and maxima. n = 10 per dose group or n = 5 for vehicle groups per experiment; data from up to 3 experiments were combined. BID twice daily, IL interleukin, ns not significant, PO orally. *P < 0.05, ***P < 0.001, ****P < 0.0001.