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. 2024 Jul 30;14:17515. doi: 10.1038/s41598-024-67371-5

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© The Author(s) 2024

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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Pharmacokinetics and pharmacodynamics of orally administered JNJ-77242113 in a first-in-human study of healthy participants. (A) Mean plasma concentrations of JNJ-77242113 in healthy participants from Part 2 (Day 1 in multiple ascending dose cohorts). Error bars denote standard deviation. (B) Mean concentrations of IL-23–induced IFNγ in whole blood from participants after they had received a single oral dose of JNJ-77242113. Error bars denote standard error of the mean. IFN interferon, IL interleukin.