Table 1.

A meta-analysis of genetic association studies with PPMS (n = 1104) in comparison to BOMS (n = 11,335)

SNPa	BP	Meta-analysis					SWE (n = 9850)		ITA (n = 2589)
		CHR	LD#	A1	P	OR	P	OR	P	OR
rs900347	145726727	1	1	A	0.0285	0.90	0.0352	0.87	0.3624	0.94
rs11800992	146501783	1	2	A	0.0093	0.82	0.0260	0.78	0.1399	0.85
rs72691008	146708291	1	3	A	0.0017	0.69	0.0083	0.69	0.0895	0.70
rs7514808	146570076	1	4	A	0.0286	0.89	0.0367	0.86	0.3632	0.93
rs72706463	146615555	1	5	A	0.0458	1.29	0.1141	1.37	0.2002	1.24
rs10453880	146693689	1	6	T	0.0065	1.26	0.1083	1.21	0.0236	1.32
rs145465008	146630173	1	7	C	0.0293	1.51	0.4867	1.17	0.0048	2.54
rs115153075	146978424	1	8	T	0.0006	1.48	0.0058	1.42	0.0303	1.74
rs12096043	147060953	1	9	T	0.0001	1.84	0.0005	2.03	0.0633	1.58
rs672619	147058575	1	10	T	0.0013	1.34	0.0374	1.32	0.0146	1.35
rs10494248	147108260	1	11	A	0.0079	1.72	0.0270	1.68	0.1386	1.82
rs140566115	147126437	1	12	A	0.0244	1.53	0.0335	1.66	0.3586	1.34
rs116430961	147312516	1	13	C	0.0101	1.62	0.1335	1.44	0.0265	1.93
rs61740912	147313970	1	14	G	0.0012	1.86	0.0098	1.81	0.0483	1.97
rs112044341	147317235	1	15	A	0.0193	1.47	0.0577	1.46	0.1707	1.49
rs74123747	147382534	1	16	T	0.0496	1.27	0.2194	1.20	0.0813	1.50

PPMS primary progressive MS, BOMS bout-onset MS (RRMS + SPMS), OR odds ratio, LD# linkage disequilibrium block, SWE Swedish cohort, ITA Italian cohort, CHR chromosome; P P-value, A1 effect allele, BP base pair (GRCh37/hg19).

^aSNP ID highlighted in bold remains significant after Bonferroni correction for multiple testing (p < 7.2 × 10⁻⁴).