Table 5.

Different strategies for overcoming the limitations of hair growth treatments.

Name	Explanation	Effect	Ref.
Dual drug delivery	Complementary drug combination Incorporating multiple drugs. Combining complementary action mechanisms.	Enhancing therapeutic efficacy Overcoming drug resistance.	[90,91]
Targeted delivery	Surface modification of NLCs Utilizing ligands, antibodies, or peptides.	Targeted delivery facilitation Reduces off-target effects. Targets specific cells/tissues.	[92,93]
Therapeutic and imaging agents	Combining therapeutic and imaging agents Fluorescent dyes or contrast agents.	Real-time drug distribution and efficacy monitoring	[94-96]
Sequential release of drugs	Drug release sequence Releases drugs at specific intervals. Response to pH, temperature, and enzymatic activity.	Optimizing drug synergy Minimizing drug interactions. Improving therapeutic outcomes. Delivering drugs at optimal time and concentration.	[97,98]
Gene and drug co-delivery	Co-delivery of therapeutic genes Utilizing siRNA, mRNA, plasmid DNA.	Targeting hair follicle regeneration pathways	[99-101]
Immunotherapy combinations	Promoting hair regrowth Targeting inflammatory processes.	Suppressing autoimmune responses and follicle proliferation	[102,103]
Personalized medicine	Tailoring combination therapy to individual patient profiles Identifying genetic markers or disease characteristics.	Optimizing treatment Minimize adverse effects.	[104,105]