Table 2:
Performance of ICD-10 Codes and Medications for the Identification of Persons with Any Ascites
| Codes/Medications | Cohort | Sensitivity (95% CI) | Specificity (95% CI) | PPV (95% CI) | NPV (95% CI) |
|---|---|---|---|---|---|
| R18.8 | Cohort 1 Retrospective compensated cirrhosis |
57.6% (44.8% - 69.7%) | 75.0% (64.1% - 84.0%) | 87.5% (82.0% - 91.5%) | 36.0% (29.9% - 44.1%) |
| Cohort 2 Prospective Child A5-B7 cirrhosis |
47.1% (22.9% - 72.2%) | 95.6% (85.2% - 99.5%) | 82.3% (52.2% - 95.2%) | 80.8% (72.8% - 86.9%) | |
| Cohort 3 Retrospective liver transplant evaluation |
40.4% (27.0% - 54.9%) | 100.0% (83.1%, 100%) | 100.0% | 39.2% (34.0% - 44.6%) | |
| Any ascites code (K70.3, R18.8, K70.11, K71.51) | Cohort 1 Retrospective compensated cirrhosis |
68.2% (55.5% - 79.1%) | 63.7% (52.2% −74.2%) | 85.1% (80.4% - 88.9%) | 39.6% (30.8 – 49.2%) |
| Cohort 2 Prospective Child A5-B7 cirrhosis |
52.9% (27.8% - 77.0%) | 93.7% (82.8% - 98.7%) | 78.4% (52.6% - 92.2%) | 82.3% (73.6% - 88.5%) | |
| Cohort 3 Retrospective liver transplant evaluation |
58.5% (44.1% - 71.8%) | 100.0% (82.3%, 100%) | 100.0% | 46.3% (38.5% - 54.3%) | |
| Loop | Cohort 1 Retrospective compensated cirrhosis |
80.3% (68.7% - 89.1%) | 55.0% (43.5% - 66.1%) | 84.4% (80.6% - 87.7%) | 47.8% (35.1% - 60.7%) |
| Cohort 2 Prospective Child A5-B7 cirrhosis |
82.3% (56.6% - 96.2%) | 89.1% (76.4% - 96.3%) | 76.4% (57.9% - 88.4%) | 92.2% (80.7% - 97.0%) | |
| Cohort 3 Retrospective liver transplant evaluation |
90.4% (78.9% - 96.8%) | 85.0% (62.1% - 96.8%) | 94.0% (84.6% - 97.8%) | 77.3% (59.1% - 88.9%) | |
| K-sparing | Cohort 1 Retrospective compensated cirrhosis |
71.2% (58.7% - 81.7%) | 57.5% (45.9% - 68.5%) | 83.6% (79.1% - 87.3%) | 39.6% (30.0% - 50.0%) |
| Cohort 2 Prospective Child A5-B7 cirrhosis |
82.3% (56.5% - 96.2%) | 93.5% (82.1% - 98.6%) | 84.4% (63.9% - 94.3%) | 92.5% (81.5% - 97.2%) | |
| Cohort 3 Retrospective liver transplant evaluation |
78.8% (65.3% - 88.9%) | 90.0% (68.3% - 98.7%) | 95.3% (84.5% - 98.7%) | 62.1% (48.7% - 73.8%) | |
| Loop+ K-sparing | Cohort 1 Retrospective compensated cirrhosis |
62.1% (49.3% - 73.8%) (49.34% - 73.78%) |
66.2% (54.8% −76.4%) | 84.9% (79.6% - 88.9%) | 36.5% (28.9% - 44.8%) |
| Cohort 2 Prospective Child A5-B7 cirrhosis |
82.3% (56.6% - 96.2%) | 93.0% (80.9% - 98.5%) | 83.5% (62.4% - 93.9%) | 92.5% (81.4% - 97.1%) | |
| Cohort 3 Retrospective liver transplant evaluation |
75.0% (61.0% - 85.9%) | 95.0% (75.1% - 99.9%) | 97.5% (85.1% - 99.6%) | 59.4% (47.4%, 70.3%) | |
| Loop + K-sparing + Code | Cohort 1 Retrospective compensated cirrhosis |
42.4% (30.3% - 55.2%) | 83.7% (73.8% - 91.0%) | 88.8% (81.8% - 93.4%) | 32.3% (27.5% - 37.5%) |
| Cohort 2 Prospective Child A5-B7 cirrhosis |
52.9% (27.8% - 77.0%) | 93.5% (82.1% - 98.6%) | 77.7% (51.6% - 91.9%) | 82.2% (73.6% - 88.5%) | |
| Cohort 3 Retrospective liver transplant evaluation |
39.2% (25.8% - 53.9%) | 100.0% (83.9%, 100.0%) | 100.0% | 40.4% 35.2% - 45.8% |
NP = negative predictive value, PPV = positive predictive value.