Table 3.
Risk of ASD from ASD PRS (continuous measure) within each category of psychiatric family history
| PRS Odds ratioa | (95% confidence limit) | p-valueb | |
|---|---|---|---|
| Psychiatric family history | |||
| ASD | 1.14 | (1.01-1.30) | 0.11 |
| Schizophrenia | 1.15 | (0.99-1.34) | 0.19 |
| Developmental/intellectual disability | 1.15 | (1.02-1.30) | 0.12 |
| ADHD | 1.29 | (1.11-1.51) | 0.87 |
| Affective disorder | 1.34 | (1.18-1.51) | 0.47 |
| Adult personality disorder | 1.28 | (1.08-1.52) | 0.94 |
| Other psychiatric disorder | 1.24 | (1.13-1.36) | 0.59 |
| No psychiatric family history | 1.27 | (1.24-1.31) | not applicable |
a
PRS Odds ratio adjusted for main effect of psychiatric family history, sex, first 5 genetic ancestry principal components (PRS), birth year, parental ages at birth, have a sibling (Y/N)
b
H0: PRS Odds ratio at each psychiatric family history category = PRS Odds ratio with no psychiatric family history vs H1: PRS Odds ratio at each psychiatric family history category ≠ PRS Odds ratio with no psychiatric family history