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. 2024 Jul 4;8(8):ziae085. doi: 10.1093/jbmrpl/ziae085

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© The Author(s) 2024. Published by Oxford University Press on behalf of the American Society for Bone and Mineral Research.

This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (https://creativecommons.org/licenses/by-nc/4.0/), which permits non-commercial re-use, distribution, and reproduction in any medium, provided the original work is properly cited. For commercial re-use, please contact journals.permissions@oup.com

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Comprehensive analysis of TNF-α stimulation-specific MSCs transcriptomes revealed that 15 immune-related genes were significantly upregulated in TNF-α-stimulated MSCs. (A) Flow chart of BMSC function-related gene screening. We analyzed DEGs of TNF-α-stimulated and unstimulated MSCs and cut-off values of p<.05 and |log2Fold Change| >5. We performed functional enrichment analysis using DAVID Version 6.8 and selected BMSC function-related biological processes. We observed highly expressed genes in the TNF-α-stimulated MSCs group with absolute log2TPM > 5. (B) Bubble plot for functional enrichment analysis of 59 genes using R v4.22. (C) Heatmap of the expression levels of selected genes with high expression in TNF-α-stimulated MSCs. (D) Table presentation of biological processes related to highly expressed genes in TNF-α-stimulated MSCs.