Fig. 2.

Affected gene expression in synovial fibroblasts and macrophages by the JAK inhibitor in arthritis. A Average expression of Il17a, Il1b, Tnf, Osm, Il6, Tnfsf11, Mmp3 and Mmp13 across all cell subtypes under untreated, CIA and CIA + JAKi conditions. B Average expression of genes in the whole samples (red dots are significantly different genes). C Number of genes whose expression was influenced by JAKi in the main clusters under CIA conditions. D Number of genes whose expression was influenced by JAKi in the myeloid and synovial fibroblast sub-clusters under CIA conditions