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. 2024 Jul 31;44:36. doi: 10.1186/s41232-024-00347-0

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© The Author(s) 2024

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 3 — Administration of the JAK inhibitor inhibits the interaction between macrophages and synovial fibroblasts. A Cell–cell communication analysis by CellPhoneDB focusing on the expression of JAK/STAT cytokines and receptors: heatmap of cell interactions under CIA (left) and CIA + JAKi (right) conditions. B Average expression of JAK/STAT cytokines and receptors in all of the mouse synovial cell subtypes. C Dot plots of JAK/STAT cytokines_receptors interaction in myeloid (myel_b and _c1-4) and synovial fibroblast (fibro_1-4) subtypes under CIA (upper) and CIA + JAKi (lower) conditions. D Dot plots of IL1B—IL1R, IL17—IL17R A/C, TNF—TNFRSF1A/B, and TNFSF11—TNFRSF11A interactions in myeloid and synovial fibroblast subtypes under CIA (upper) and CIA + JAKi (lower) conditions