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. 2024 Jul 31;44:36. doi: 10.1186/s41232-024-00347-0

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© The Author(s) 2024

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 4 — The JAK inhibitor targets the OSM signaling in synovial fibroblasts. A Normalized enrichment scores analyzed by GSEA. Heatmap of all clusters in CIA vs. CIA + JAKi conditions using JAK/STAT-related cytokine signaling and RA gene sets with FDR adjusted-p < 0.05. B The highest NES (GSEA) responses between CIA vs. CIA + JAKi conditions. C Heatmaps of the average signature scores of all the mouse synovial cell subtypes. using 15 JAK/STAT pathway cytokine target gene sets under CIA (left) and CIA + JAKI (right) conditions