Table 3.

Summary of selected studies of BV treatment after brain radiation necrosis (omitted studies with exclusively glioma patients)

Study	Protocol	No of pts	Lesion type	BV dose/ cycles	Clinical response	T1 radiologic response	T2 radiologic response	Serious (grade > 3) side effects	Relapse
[5]	Prospective RCT (with crossover)	14	Brain tm/ H&N	7.5 mg/kg 4 cycles	All treated patients	63% volume decrease	59% volume decrease	2 thrombosis 1 asp pneumonia	2 patients
[6]	Prospective RCT	112 /58 BV	NF ca.	5 mg/kg 4 cycles	62.1% vs. 42.6%	25.5% volume decrease	51.8% volume decrease	1 ischemic stroke	12/58 on BV arm
[8]	Prospective, single arm	21	Metastasis	1 mg/kg 3 cycles	90%	95.2% intensity decrease	95% volume decrease	No Grade > 2	Not reported
[14]	Prospective, single arm	10	Mostly AVM	2.5 mg/kg 1 dose	80%	74% volume decrease	50% volume decrease	No serious side effects	2 patients
[10]	Meta-analysis (mostly retrospective)	89	Metastasis	various	88%	47.03% volume decrease	61.78% volume decrease	1/63 of reported Grade 3 pulm. thrombosis	15 patients
[9]	Systemic review (mostly retrospective)	236	Metastasis/ brain tm/ H&N	various	91%	50% volume decrease	59% volume decrease	5 Gr3: 3 thrombosis 1 ischemic stroke 1 asp pneumonia	46/135 reported (34%)
[15]	Retrospective	40	Metastasis	various	67.5%	75% volume decrease	76.2% volume decrease	No serious side effects	Not reported
[16]	Retrospective	45	Metastasis/brain tm/ other	7.5 mg/kg 4 cycles		49.3% volume decrease	62.3% volume decrease	2 cerebral hemorrhages	8 patients
[17]	Retrospective	95 (41 BV)	Metastasis	various	27/41 BV patients (65.9%)	28.7% diameter decrease	43.7% diameter decrease	2 Gr. 4 bleeding 1 Gr. 3 GIS toxicity 1 Gr 3 allergy	23/41 BV patients (56%)
This study	Retrospective	40	Metastasis	various	77.5%	25% volume decrease	62.2% volume decrease	Not reported	8 patients