Figure - PMC

Skip to main content

An official website of the United States government

Here's how you know

Here's how you know

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

View full-text article in PMC

. 2024 Jul 31;12:121. doi: 10.1186/s40478-024-01828-6

Search in PMC
Search in PubMed
View in NLM Catalog
Add to search

© The Author(s) 2024

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.

PMC Copyright notice

Fig. 1 — Radiological and pathological findings in case 1. A Axial CT images at the age of 74 years. Mild atrophy was noted in the amygdala, but the neocortex was almost completely spared. Bilateral Sylvian fissures were slightly dilated. B, C Axial (B) and coronal (C) CT images at age 86. Atrophy in the amygdala became severe. Atrophy in the neocortex was diffuse and symmetric but was slightly accentuated in the frontotemporal lobes. D–F Macroscopic findings of coronal sections of the left hemisphere. Scale bars = 1 cm. G AGs in the amygdala. Gallyas method. Scale bar = 30 μm. H Severe neuronal loss with gliosis in the globus pallidus. The degeneration is more evident in the internal segment (especially in the dorsal portion) than in the external segment in the site. Put: the putamen. H&E stain. Scale bar = 200 μm. I The same region shown in (H). Fibrillary gliosis is more evident in the internal segment rather than the external segment in the globus pallidus. Holzer stain. Scale bar = 200 μm. J–L Severe neuronal loss with gliosis in the globus pallidus revealed by H&E stain (J) and GFAP immunohistochemistry (K). Tau accumulation in the same region (L). AT8 immunohistochemistry. All scale bars = 20 μm. A–C Reprinted with permission from reference [66]