Figure - PMC

Skip to main content

An official website of the United States government

Here's how you know

Here's how you know

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

View full-text article in PMC

. 2024 Jul 31;12:121. doi: 10.1186/s40478-024-01828-6

Search in PMC
Search in PubMed
View in NLM Catalog
Add to search

© The Author(s) 2024

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.

PMC Copyright notice

Fig. 5 — Tau immunoblot and immunoelectron microscopy of the sarkosyl-insoluble, urea-soluble fraction from brains in diffuse form pAGD cases. A, B Tau immunoblot analysis in cases 1 and 2 with AT8 (A) and T46 (B). Approximately 68- and 64-kDa bands were noted in all regions examined in cases 1 and 2. Low molecular weight tau fragments of approximately 22-kDa band and 37-kDa doublet were also noted in both cases. Weak 60-kDa bands that suggest tau accumulation as AD pathology were noted in the amygdala and inferior temporal gyrus in case 2. C–F Immunoelectron microscopy of sarkosyl-insoluble tau from brains in cases 1 (C, D) and 2 (E, F). AT8 was used as a primary antibody and was labeled by secondary antibody conjugated to 15-nm gold particles. AT8-positive twisted ribbon-like filaments were noted in both cases. PH: parahippocampal gyrus; IT: inferior temporal gyrus; MF: middle frontal gyrus; CN: caudate nucleus; AM: amygdala