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. Author manuscript; available in PMC: 2024 Jul 31.
Published in final edited form as: Nat Cancer. 2023 May 29;4(6):893–907. doi: 10.1038/s43018-023-00563-6

Fig. 5 |. Phospho-DRP1 is elevated in human metachronous brain metastases.

Fig. 5 |

a, IHC staining for p-DRP1S616 (1:200, DAB, 10×) in matched human HER2+ PT and metachronous brain metastases (Br. Met). b, Representative graph showing histoscore of p-DRP1S616 in HER2+ PT and matched brain metastatic samples (n = 7, each group). c, Bar graph showing spine and brain-only photon flux in mice bearing Ctrl (n = 9) and DRP1-depleted (n = 9) M-BM cells. d,e, Ex vivo brain images (d) and brain-only photon flux (e) showing metastatic burden in mice bearing Ctrl (n = 9) and DRP1-depleted (n = 8) M-BM cells. In b, ‘n’ represents number of human patients, and in c and d, ‘n’ represents number of mice. Data are presented as mean ± s.e.m. P value in b was calculated by two-tailed paired t-test, and in c and d, P values were calculated by two-tailed Mann–Whitney U-test.