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. 2013 Aug 31;2013(8):CD006574. doi: 10.1002/14651858.CD006574.pub4

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Trial sequential analysis of operating time (abdominal wall lift without pneumoperitoneum versus pneumoperitoneum) 
 Trial sequential analysis of operating time showing that the cumulative Z‐curve crosses the trial sequential monitoring boundary after the tenth trial. The diversity‐adjusted required information size (DARIS) was 304 participants based on a minimal relevant difference (MIRD) of 15 minutes, a variance (VAR) of 384.2, an alpha (a) of 5%, a beta (b) of 20%, and a diversity (D2) of 82.29%. The results are compatible with significantly higher operating time in the abdominal wall lift group compared with pneumoperitoneum group without risk of random errors.