Comparison 1. Anthracycline versus no anthracycline same chemotherapy.

Outcome or subgroup title	No. of studies	No. of participants	Statistical method	Effect size
1 Overall survival	3	464	Hazard Ratio (95% CI)	0.99 [0.77, 1.29]
2 Overall survival with Zinzani	4	663	Hazard Ratio (95% CI)	0.97 [0.76, 1.23]
3 Mortality at 3 years	3	465	Risk Ratio (M‐H, Fixed, 95% CI)	0.92 [0.67, 1.26]
4 Mortality at 5 years	3	465	Risk Ratio (M‐H, Fixed, 95% CI)	0.95 [0.77, 1.18]
5 Complete response	5	881	Risk Ratio (M‐H, Fixed, 95% CI)	1.05 [0.94, 1.18]
6 Overall response	3	616	Risk Ratio (M‐H, Fixed, 95% CI)	1.06 [1.00, 1.12]
7 Disease control	4	759	Hazard Ratio (95% CI)	0.65 [0.52, 0.81]
7.1 Progression‐free survival	2	514	Hazard Ratio (95% CI)	0.65 [0.50, 0.84]
7.2 Response duration	2	245	Hazard Ratio (95% CI)	0.63 [0.40, 0.98]
8 Progression/relapse at 3 years	4	724	Risk Ratio (M‐H, Fixed, 95% CI)	0.73 [0.63, 0.85]
9 Neutropenia grade 3‐4	2	533	Risk Ratio (M‐H, Fixed, 95% CI)	1.94 [1.46, 2.56]
10 Infection	3	1185	Risk Ratio (M‐H, Fixed, 95% CI)	1.16 [0.75, 1.80]