Figure - PMC

Skip to main content

An official website of the United States government

Here's how you know

Here's how you know

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

View full-text article in PMC

. 2024 Jun 13;134(15):e165734. doi: 10.1172/JCI165734

Search in PMC
Search in PubMed
View in NLM Catalog
Add to search

© 2024 Hsieh et al.

This work is licensed under the Creative Commons Attribution 4.0 International License. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

PMC Copyright notice

(A) Representative gross images of Tp53-KO (Albumin-Cre; Tp53^fl/fl; n = 4), Lin28a/Tp53-DKO (Albumin-Cre; Tp53^fl/fl; Lin28a^fl/fl; n = 5), and Lin28b/Tp53-DKO (Albumin-Cre; p53^fl/fl; Lin28b^fl/fl; n = 4) mice that received NRAS^G12V by HDT for 7 weeks. Scale bars: 1 cm; 5 mm (right panels). (B) Liver-to-body weight ratios for A. One-way ANOVA was performed. (C) Representative gross images of Lin28a/Lin28b/Tp53-TKO mice that received NRAS^G12V in combination with pT3-eGFP (n = 5), pT3-LIN28A (n = 8), or pT3-LIN28B (n = 3) for 7 weeks. Scale bars: 1 cm; 5 mm (right panels). (D) Liver-to-body weight ratios for C. One-way ANOVA was performed. (E) Representative gross images of Lin28a/Lin28b/Tp53-TKO mice that received NRAS^G12V combined with pCMV-eGFP (n = 4) or pCMV-LIN28B (n = 4) for 7 weeks. Scale bars: 1 cm; 5 mm (right panels). (F) Liver-to-body weight ratios for E. **P < 0.01; ***P < 0.001.