Table 2:

Mixed model analysis comparing the humoral immune response elicited in the plasma and airways by ID BCG versus IV BCG at different time points.

Niche	Immunoglobulin	BCG ID vs. BCG IV	P-value		Mean Difference: BCG ID - BCG IV (95% CI)
Plasma	IgG WCL	PreBCG	0.3107	ns
		4 weeks post BCG	0.0421	*	−1.095 (−2.140 to 0.04976)
		18 weeks post BCG	0.04	*	−0.4427 (−0.8598 to −0.0255)
	IgM WCL	PreBCG	0.432	ns
		4 weeks post BCG	0.3434	ns
		18 weeks post BCG	0.1954	ns
	IgG LAM	PreBCG	0.5487	ns
		4 weeks post BCG	0.5161	ns
		18 weeks post BCG	0.8804	ns
	IgM LAM	PreBCG	0.3632	ns
		4 weeks post BCG	0.0039	**	−0.8388 (−1.227 to −0.4506)
		18 weeks post BCG	0.432	ns
BAL (airway)	IgG WCL	PreBCG	0.7060	ns
		4 weeks post BCG	0.0016	**	−1.305 (−2.141 to −0.4682)
		18 weeks post BCG	0.1002	ns
	IgM WCL	PreBCG	>0.9999	ns
		4 weeks post BCG	0.3160	ns
		18 weeks post BCG	0.4222	ns
	IgG LAM	PreBCG	0.0878	#	−1.180 (−2.466 to 0.1059)
		4 weeks post BCG	0.006	**	−1.841 (−3.099 to −0.5823)
		18 weeks post BCG	0.0222	*	−1.752 (−3.229 to −0.2744)
	IgM LAM	PreBCG	0.0727	#	−0.8621 (−1.810 to 0.08572)
		4 weeks post BCG	0.0975	#	0.7920 (−1.7840 to 0.1558)
		18 weeks post BCG	0.0240	*	−1.300 (−2.413 to −0.1864)

ID and IV BCG were compared at each time point for each cell type. Fisher’s LSD test p-values reported.

For p-values < 0.10, the mean difference of ID BCG - IV BCG is shown with 95% confidence interval.

The summary of p-value is presented;

^#:0.05 < p < 0.10,

^*:p < 0.05,

^**:p < 0.01 and

^***:p < 0.001.

WCL: H37Rv whole cell lysate, LAM: Lipoarabinomannan.