FIGURE 5.

Lymphatic drainage is decreased in male Panx1 ^LECdel mice. Interstitial fluid drainage was measured by quantification of Evans blue in the sera of Panx1 ^fl/fl (white bars) and Panx1 ^LECdel female (a) (gray bars; N = 10) and male mice (b) (patterned gray bars; N = 10). (c) Representative images of Hematoxylin/Eosin stained cryosections of tails from Panx1 ^fl/fl and Panx1 ^LECdel mice. Tail diameter in Panx1 ^fl/fl and Panx1 ^LECdel mice was measured at 1 cm from the tip in female (d) and male (e) mice (N = 10). Two‐tailed Student's t‐test.