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A) Circular dichroism spectra of full-length D10 (blue) and D10-NT (black). B) Thioflavin T monitored aggregation of purified recombinant D10-NT. C) TEM micrograph of aggregated D10-NT. D) Skin fibroblasts from p.R15L D10 patients immunostained for D10 (red) and co-stained with Thioflavin S (green) showing colocalization (arrows) E) TEM micrograph of D10-immunogold labeled sarkosyl insoluble fraction of heart tissue from a D10S55L mouse.
