Figure 3: Morphomolecular analysis of increased mitosis in danazol.

a. For each slide-expression pair, we correlate the predicted percentage of mitosis found in the slide with the measured gene expression. Genes with a high correlation between measured expression and predicted lesion extent can be seen as part of the morphomolecular signature associated with the compound. TG-GATEs original annotations report 8/64 slides with increased mitosis in danazol. b. Correlation between the estimated percentage of the mitosis in a slide and the gene expression of CCNB2 and CDCA3 (left: measured, right: predicted). P-value derived from testing the two-sided null hypothesis of non-correlation. c. Density distribution of patch-level expression for patches predicted as normal by the lesion classifier (n=746,699 patches) and patches predicted as containing mitosis (n=26,429). Patches were extracted from the 64 WSIs of the danazol study.