Figure 5: Pathway enrichment analysis and human in vitro validation.

a. Pathway enrichment analysis of GEESE-identified genes uniquely linked to necrosis in rat and human biological processes. b,c. Enrichment analysis conducted for hypertrophy and increased mitosis. Additional analysis is provided in fig. S12,13,14,15,16, and 17. d. Translation to in vitro primary human hepatocyte cell lines in the gene set uniquely identified as linked to necrosis (in vivo) with a focus on the 33 upregulated and 33 downregulated genes identified as related to necrosis.