Fig. 5. Genetic or pharmacologic inhibition of IL-11 extends life expectancy of male and female mice.
a–c, Kaplan–Meier survival curves (shading represents 95% confidence interval) showing the cumulative survival probabilities for male (a), female (b) and sex-pooled (c) wild-type and Il11−/− mice. d–f, Kaplan–Meier survival curves showing the cumulative survival probabilities for male (d), female (e) and sex-pooled (f) mice, comparing those receiving monthly administration of IgG or X203 (40 mg kg−1, intraperitoneal injection), starting from 75 weeks of age (red dotted line). Statistical significance (two-tailed P value) was assessed by means of the log-rank (Mantel–Cox) and Wilcoxon test for survival curve comparisons.