FIGURE 3.

Inter-atrial AF cycle length gradient. (A) In all groups with stable baseline AF (27 animals), a gradient of the AF cycle length (AFCL) was present in baseline recordings. A somewhat smaller gradient was present during the 10 s before AF termination (33 animals, 79 terminations). This gradient gradually decreased with a full disappearance at 250 m before AF termination. (B) Individual group data revealed strong reduction of the AFCL gradient for Spontaneous termination, PA-6 and vernakalant. The AFCL gradient for AP14145 and XAF-1407 remained statistically different. Statistical analysis was performed with a mixed model. Terminations per group (animals per group); Acute AF n = 8 (4), Spontaneous termination n = 6 (2), AP14145 n = 13 (5), PA-6 n = 14 (6), Vernakalant n = 16 (8) and XAF-1407 n = 22 (8). AF, atrial fibrillation; **p < 0.01, ***p < 0.001, ****p < 0.0001, and n.s. Not significant.