TABLE 1.

Electrophysiological changes from baseline to the final 10 s before AF termination. Statistical analysis of the differences between baseline and AF termination was performed with a paired t-test (**p < 0.01, ***p < 0.001). Statistical analysis of the differences between the left and right atrium was performed with an unpaired t-test (^# p < 0.05,^## p < 0.01,^### p < 0.001). Number of animals (and terminations) per group; All n = 33 (79), Acute AF n = 4 (8), Spontaneous termination n = 2 (6), AP14145 n = 5 (13), PA-6 n = 6 (14), Vernakalant n = 8 (16) and XAF-1407 n = 8 (22).

	Right atrium		Left atrium
	Baseline	AF termination	Baseline	AF termination
AFCL (ms)
All	99 ± 20	152 ± 28***	133 ± 18###	170 ± 27***,###
Acute AF	—	125 ± 7	—	126 ± 7
Spontaneous termination	—	135 ± 13	—	150 ± 4#
AP14145	111 ± 21	158 ± 17***	145 ± 11#	188 ± 12***,###
PA-6	111 ± 19	144 ± 22**	137 ± 24	158 ± 21
Vernakalant	84 ± 15	178 ± 33***	117 ± 13###	191 ± 26***
XAF-1407	93 ± 13	145 ± 22***	135 ± 14###	166 ± 16***,###
Conduction velocity (cm/s)
All	52.8 ± 4.7	58.4 ± 8.2**	56 ± 4#	56.6 ± 8.3
Acute AF	—	61.1 ± 4.2	—	61.7 ± 5.7
Spontaneous termination	—	59.8 ± 5	—	62.3 ± 3.2
AP14145	56.9 ± 3.3	57.6 ± 6.4	56.1 ± 2.1	53.7 ± 6.2
PA-6	53.3 ± 2.5	56.9 ± 4.5	54.5 ± 4.5	57.4 ± 6.9
Vernakalant	46.9 ± 2.8	49.8 ± 5.4	56.4 ± 5.9##	50.3 ± 9.5
XAF-1407	55.4 ± 1.9	65.3 ± 7.9**	56.7 ± 2.3	60.3 ± 6.7
Path length (cm)
All	5.2 ± 1.2	8.9 ± 1.7***	7.4 ± 1.1###	9.5 ± 1.4***,#
Acute AF	—	7.6 ± 0.5	—	7.8 ± 1
Spontaneous termination	—	8.2 ± 0.8	—	9.4 ± 0.7#
AP14145	6.3 ± 1.2	9.3 ± 1.7**	8.1 ± 0.9#	10.2 ± 1.4**
PA-6	5.8 ± 0.9	8.2 ± 1.2***	7.4 ± 1#	9.1 ± 1.2**
Vernakalant	3.9 ± 0.8	9 ± 1.8***	6.6 ± 1.2###	9.5 ± 1.5***
XAF-1407	5.2 ± 0.8	9.6 ± 2.1***	7.6 ± 0.8###	10 ± 1.1***