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In vitro metabolic kinetics of butonitazene, isotonitazene and protonitazene in human liver microsomes and S9 fractions.
| Compound | Human liver microsomes | Human liver S9 | ||||
|---|---|---|---|---|---|---|
| Metabolism (%) | Half-life (min) | CLint (µL/min/mg protein) | Metabolism (%) | Half-life (min) | CLint (µL/min/mg protein) | |
| Butonitazene | 100 | 4 | 309 | 97 | 8 | 217 |
| Isotonitazene | 100 | 6 | 221 | 96 | 10 | 139 |
| Protonitazene | 100 | 6 | 216 | 97 | 9 | 150 |
| Verapamil/Testosterone | 96 | 9 | 150 | 47 | 40 | 35 |
