TABLE 4.
The depletion of butonitazene, isotonitazene and protonitazene in recombinant cytochrome P450 enzymes.
| CYP | Extent of metabolism after 30 min (%) | |||
|---|---|---|---|---|
| Control substrate a | Butonitazene | Isotonitazene | Protonitazene | |
| CYP1A2 | 42 | 3 | 9 | 12 |
| CYP2A6 | 81 | 20 | 32 | 25 |
| CYP2B6 | 40 | 85 | −5 | 97 |
| CYP2C8 | 80 | 34 | 44 | 44 |
| CYP2C9 | 95 | 17 | −7 | −6 |
| CYP2C19 | 25 | −9 | 0 | 16 |
| CYP2D6 | 100 | 99 | 54 | 98 |
| CYP2E1 | 80 | 26 | 42 | 42 |
| CYP3A4 | 66 | 6 | −12 | 5 |
a
Phenacetin (CYP1A2); Diclofenac (CYP2C9); S-Mephenytoin (CYP2C19); Dextromethorphan (CYP2D6); Testosterone (CYP3A4); Coumarin (CYP2A6); Bupropion (CYP2B6); Amodiaquine (CYP2C8); Chlorzoxazone (CYP2E1).