TABLE 5.
Metabolic kinetics of butonitazene, isotonitazene and protonitazene in recombinant cytochrome P450 enzymes.
| Compound | Matrix | % metabolism | Half-life (min) | Clint (µL/min/100 pmol) |
|---|---|---|---|---|
| Butonitazene | CYP2D6 | 99 | 2 | 920 |
| CYP3A4 | 44 | 22 | 64 | |
| CYP2B6 | 83 | 10 | 137 | |
| Isotonitazene | CYP2D6 | 72 | 9 | 153 |
| CYP3A4 | 53 | 18 | 78 | |
| CYP2C8 | 48 | 13 | 108 | |
| Protonitazene | CYP2D6 | 100 | 1 | 960 |
| CYP3A4 | 54 | 16 | 85 | |
| CYP2B6 | 96 | 5 | 290 | |
| CYP2C8 | 41 | 44 | 31 | |
| Dextromethorphan | CYP2D6 | 100 | 1 | 1,193 |
| Testosterone | CYP3A4 | 94 | 9 | 154 |
| Bupropion | CYP2B6 | 58 | 22 | 62 |
| Amodiaquine | CYP2C8 | 82 | 9 | 149 |