TABLE 7.
Analysis of the putative metabolites of butonitazene in human liver microsomes and liver S9 fractions.
| Ion/Fragment | % relative intensity (sum intensity) | % relative abundance (peak area) | % relative intensity (sum intensity) | % relative abundance (peak area) |
|---|---|---|---|---|
| Human liver microsomes | Human liver S9 | |||
| Butonitazene | ||||
| Hydroxylation | 0.4 | 0.4 | 0.7 | 0.7 |
| N-Desethylation | 51 | 50 | 28 | 27 |
| Dealkylation | 2.5 | 2.6 | 1.2 | 1.4 |
| Desethylation + Dealkylation | 16.3 | 16.3 | 8.1 | 8.6 |
| Desethylation + Hydroxylation | 1.7 | 1.9 | 1.3 | 1.6 |
| Isotonitazene | ||||
| Hydroxylation | 0.5 | 0.5 | 0.3 | 0.3 |
| N-Desethylation | 27 | 33 | 30 | 25 |
| Dealkylation | 0.02 | 0.02 | - | - |
| N-Desethylation + Dealkylation | 0.98 | 1.20 | 0.6 | 0.9 |
| N-Desethylation + Hydroxylation | 0.2 | 0.2 | 0.1 | 0.2 |
| Depropylated-demethylated | 1.2 | 1.4 | 0.9 | 0.8 |
| N-De-ethylamination and Dealkylation | 0.1 | 0.1 | 0.1 | 0.1 |
| N-desethylation, debutylation | 0.7 | 0.8 | 0.5 | 0.5 |
| Protonitazene | ||||
| Hydroxylation | 0.3 | 0.4 | 0.5 | 0.4 |
| N-Desethylation | 41 | 37 | 31 | 30 |
| Dealkylation | 0.16 | 0.19 | 0.6 | 0.8 |
| N-Desethylated + Dealkylated | 0.71 | 1.05 | 0.7 | 0.9 |
| Demethylated + Dealkylated | 1.8 | 1.9 | 1.0 | 1.1 |
| De-aminopentylated | 0.08 | 0.09 | 0.4 | 0.5 |
| N-Desethylation + Hydroxylation | 1.0 | 1.0 | 1.0 | 0.9 |