Table 2. Clinical characteristics, diagnosis, treatment and prognosis of cats with feline calicivirus-associated viral systemic disease in Korea.

Case No.		Onset of clinical symptoms	Clinical symptoms	Areas affected by limb edema	Calicivirus statusa	Sampling site (result) for RT-qPCR	Diagnosis of FCV-VSDb	rFeIFN-ω treatment	Outcome
Outbreak 1
	1	04/Mar	Anorexia, lethargy, fever, limb edema, nasal discharge, sneezing, ocular discharge, ulcerative dermatitis	All four limbs	Unavailable		Suspected	X	Died
	2	23/Mar	Anorexia, lethargy, fever, limb edema, ulcerative dermatitis, nasal discharge, sneezing	All four limbs	Positive	Oral/laryngeal (+), blood (-)	Confirmed	X	Died
	3	26/Mar	Anorexia, lethargy, fever, hypersalivation, jaundice		Unavailable		Suspected	X	Died
	4	26/Mar	Anorexia, lethargy, fever, limb edema, ulcerative dermatitis, hypersalivation, vomiting	Lt forelimb	Negative	Oral/laryngeal (-), blood (-)	Suspected	O	Survived
	5	02/Apr	Anorexia, lethargy, fever, facial/limb edema, cough	Rt forelimb and Rt hindlimb	Positive	Oral/laryngeal (-), blood (-), liver tissue (+)	Confirmed	X	Died
	6	29/Mar	Anorexia, lethargy, fever, limb edema, crusting skin lesions, delayed wound healing	All four limbs	Unavailable		Suspected	X	Died
	7	27/Mar	Anorexia, lethargy, fever, facial/limb edema	Lt forelimb and Lt hindlimb	Negative	Oral/laryngeal (-), blood (-)	Possible	X	Died
	8	29/Mar	Lethargy, fever, oral ulceration, ulcerative keratitis, limb edema	All four limbs	Positive	Oral/laryngeal (+)	Confirmed	X	Died
	9	04/Apr	Lethargy, oral ulceration, ulcerative keratitis, facial edema		Negative	Oral/laryngeal (-)	Possible	O	Survived
	10	17/Apr	Anorexia, lethargy, fever, facial/limb edema, ulcerative dermatitis	Forelimbs	Positive	Oral/laryngeal (+), skin (+)	Confirmed	X	Survived
	11	09/May	Anorexia, lethargy, dull mental status, limb edema, jaundice	All four limbs	Positive	Oral/laryngeal (+), blood (-)	Confirmed	X	Died
	12	11/May	Anorexia, lethargy, fever, limb edema	Rt forelimb and Rt hindlimb	Positive	Skin (+), liver tissue (+)	Confirmed	X	Died
Outbreak 2
	13	15/Aug	Anorexia, nausea, fever, nasal discharge		Positive	Oral/laryngeal (-), skin (+)	Confirmed	X	Died
	14	25/Aug	Anorexia, fever, limb edema, diarrhea	Forelimbs	Positive	Oral/laryngeal (-), skin (+)	Confirmed	O	Survived
	15	29/Aug	Lethargy, facial/limb edema, delayed wound healing, nasal discharge, dyspnea, cough, pneumonia	All four limbs	Positive	Oral/laryngeal (+), blood (-)	Confirmed	X	Survived
	16	28/Aug	Anorexia, fever, facial edema		Positive	Oral/laryngeal (+), skin (-), blood (-)	Confirmed	O	Died
	17	26/Aug	Anorexia, lethargy, fever, limb edema, delayed wound healing	Hindlimbs	Unavailable		Suspected	X	Died
	18	06/Sep	Anorexia, lethargy, jaundice, hindlimb limping without edema		Positive	Oral/laryngeal (+), blood (-)	Confirmed	O	Died

FCV-VSD, feline calicivirus-associated viral systemic disease; RT-qPCR, reverse transcription quantitative real time polymerase chain reaction; rFeIFN-ω, recombinant-feline interferon-omega; Lt, left; Rt, right.

^aDetection of callicivirus by RT-qPCR.

^bAccording to exposure history, clinical signs, and RT-qPCR results, patients were classified as confirmed, suspected, or possible FCV-VSD.