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Aire both activates and represses the transcription of a multitude of transcripts. (A) RNA from WT and aire KO thymi was hybridized to Affymetrix MgU74Av2 microarrays. Expression level vs. fold change (WT/KO) is plotted for all 12,000 probesets, showing that aire's absence affects the transcription of many genes. (B) Randomized data.
