Table 3.
Selected associations of SDOH with MRS CpG sites in JHS.
| Trait, B(SE) | cg12116137 (PRPF8) | cg17944885 (ZNF788; ZNF20) | cg00501876 (CSRNP1) |
|---|---|---|---|
| Individual | |||
| Alcohol use | n.s | n.s | − 0.0078 (0.0025) |
| Physical activity | n.s | n.s | 0.0034 (0.0015) |
| Insured | n.s | − 0.0056 (0.0028) | n.s |
| Depression | n.s | 0.0003 (0.0001) | − 0.0004 (0.0002) |
| Perceived stress | -0.0012 (0.0005) | n.s | n.s |
| Neighborhood | |||
| Problems | n.s | 0.0147 (0.0052) | n.s |
| SES | n.s | − 0.0007 (0.0003) | 0.0008 (0.0003) |
| Violence | n.s | 0.0203 (0.0077) | n.s |
| Poverty | n.s | 0.0170 (0.0075) | − 0.0226 (0.0095) |
| AA Density | n.s | 0.0195 (0.0036) | − 0.0098 (0.0045) |
Beta estimates presented for a CpG beta score ~ Trait. Linear mixed models were adjusted for age, sex, PC1-PC4, cell counts, and family (random). N.S.: not significant (p > 0.05).