Table 1.

Characteristics of UKBB participants with plasma proteomic profiling (N = 46,237).

Characteristic	Myeloid neoplasm development		Overall (N = 46,237)	P
	Yes (N = 115)	No (N = 46,122)
Age, mean (SD; y)	60.79 (7.5)	57.31 (8.2)	57.32 (8.2)	2.1E−06
Sex, female	48 (41.7%)	24,770 (53.7%)	24,818 (53.7%)	0.01
Race				0.82
White	110 (95.7%)	42,973 (93.2%)	43,083 (93.2%)
Black	2 (1.7%)	1,068 (2.3%)	1,070 (2.3%)
Asian	2 (1.7%)	1,016 (2.2%)	1,018 (2.2%)
Other	1 (0.9%)	836 (1.8%)	837 (1.8%)
Missing	0 (0%)	229 (0.5%)	229 (0.5%)
Smoking status				4.7E−03
Never	47 (40.9%)	24,968 (54.1%)	25,015 (54.1%)
Current or former	68 (59.1%)	20,936 (45.4%)	21,004 (45.4%)
Missing	0 (0%)	218 (0.5%)	218 (0.5%)
Blood counts, mean (SD)
Neutrophil count, ×109 cells/L	4.42 (2.1)	4.24 (1.4)	4.24 (1.4)	0.38
Lymphocyte count, ×109 cells/L	1.90 (0.7)	1.95 (0.7)	1.95 (0.7)	0.44
Monocyte count, ×109 cells/L	0.59 (0.6)	0.48 (0.2)	0.48 (0.2)	0.04
Eosinophil count, ×109 cells/L	0.17 (0.1)	0.17 (0.1)	0.17 (0.1)	0.75
Basophil count, ×109 cells/L	0.04 (0.1)	0.03 (0.0)	0.03 (0.0)	0.65
Hemoglobin concentration, g/dL	13.9 (1.4)	14.2 (1.3)	14.2 (1.3)	0.05
Mean corpuscular volume, fL	92.4 (7.4)	91.1 (4.6)	91.1 (4.6)	0.06
RBC distribution width (%)	14.3 (1.8)	13.5 (1.0)	13.5 (1.0)	5.0E−06
Platelet count, ×109 cells/L	299 (126)	252 (59)	252 (59)	1.7E−04
Clonal hematopoiesis (CH)
Detectable	49.6%	8.60%	8.7%
CH-heme (SNV/indel)	49 (42.6%)	2,757 (6.0%)	2,806 (6.1%)	2.6E−29
0 variants	66 (57.4%)	43,365 (94.0%)	43,431 (93.9%)	1.6E−126
1 variant	32 (27.8%)	2,538 (5.5%)	2,570 (5.6%)
≥2 variants	17 (14.8%)	219 (0.5%)	236 (0.5%)
Mean VAF, mean (SD)	0.26 (0.1)	0.15 (0.1)	0.15 (0.1)	6.0E−08
CH-mCA	23 (20.0%)	1,369 (3.0%)	1,392 (3.0%)	5.5E−13

Note: Unless noted otherwise, data are n (%).

Abbreviations: SD, standard deviation; SNV, single-nucleotide variant; VAF, variant allele frequency; mCA, mosaic chromosomal alteration.