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. 2024 May 24;30(15):3316–3328. doi: 10.1158/1078-0432.CCR-24-0753

Figure 2.

Figure 2.

Droplet digital PCR maintains linearity for ALK F1174L and ALK R1275Q with or without WGS libraries process. A, Comparison analysis of measured ALK R1275Q VAFs’ (%) average (n = 4) in ddPCR between two conditions: with WGS libraries process or no WGS libraries process for each group of dilutions. B, Comparison analysis of measured ALK F1174L VAFs’ (%) average (n = 4) in ddPCR between two conditions, with WGS libraries process or no WGS libraries process for each group of dilutions. Comparison of the VAF means of the quadruplicates of each dilution demonstrated that no statistically significant difference was observed between the two conditions (Mann–Whitney test; P < 0.05). C, Correlation analysis of measured ALK R1275Q VAFs (%) without or with WGS libraries process obtained by calculating an average on four replicates (n = 4) represented respectively in the x-axis and the y-axis (as mean ± SD; n ≥ 3). Pearson’s correlation coefficient (r) and P-value are indicated. D, Correlation analysis of measured ALK F1174L VAFs (%) without or with WGS libraries process obtained by calculating an average on four replicates (n = 4) represented respectively in the x-axis and the y-axis (as mean ± SD; n ≥ 3). Pearson’s correlation coefficient (r) and P-value are indicated.