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. 2024 Jul 15;15(7):1537–1550. doi: 10.4239/wjd.v15.i7.1537

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©The Author(s) 2024. Published by Baishideng Publishing Group Inc. All rights reserved.

This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial.

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The left-side\right-side\mean diffusion tensor image analysis method along the perivascular space index was evaluated. A: The diffusion tensor image analysis method along the perivascular space (DTI-ALPS) index of the left-side cerebral hemisphere in patients with type 2 diabetes mellitus (T2DM) was significantly lower than in the normal glucose metabolism (NGM) group; B: The DTI-ALPS index of the right cerebral hemisphere in patients with T2DM was significantly lower than that in the prediabetes group and the NGM group; C: The mean DTI-ALPS index of both cerebral hemispheres in patients with T2DM was significantly higher in the prediabetes and NGM groups. T2DM: Type 2 diabetes mellitus; NGM: Normal glucose metabolism; DTI-ALPS: Diffusion tensor image analysis method along the perivascular space; L-DTI-ALPS: Diffusion tensor image analysis method along the perivascular space index of the left cerebral hemisphere in prediabetes and type 2 diabetes mellitus; R-DTI-ALPS: Diffusion tensor image analysis method along the perivascular space index of the right cerebral hemisphere of prediabetes and type 2 diabetes mellitus; Mean-DTI-ALPS: Mean Diffusion tensor image analysis method along the perivascular space index in both cerebral hemispheres.