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. 2024 Jul 1;86:101983. doi: 10.1016/j.molmet.2024.101983

Figure 2.

Figure 2

Adipocyte specific miPEP deletion reduces adiposity and increases insulin sensitivity (A) Western blotting against miPEP in control (miPEPfl/fl) or adipocyte specific KO mice (aKO) obtained from isolated adipocytes. (B) Oral Glucose tolerance test (C) Fasting blood glucose (D) Blood insulin (fasting and at 15 min during Oral Glucose tolerance test). Mean ± S.D., N = 7, ∗p < 0.05 vs miPEPfl/fl mice. (E) Intraperitoneal insulin tolerance test (F) Area of the curve during insulin tolerance test. Mean ± S.D., N = 3, ∗p < 0.05 vs miPEPfl/fl mice. (G) Temporal changes in fat mass (H) Adiposity at 22 wks old. N = 4–6, mean ± S.D. ∗∗p < 0.01, ∗∗∗∗p < 0.0001 vs miPEPfl/fl. (I) Representative image of adipose depots in miPEPfl/fl and aKO mice. gWAT: Gonadal white adipose tissue, SAT: Subcutaneous white adipose tissue, BAT: Brown adipose tissue. Scale bar 1 cm. Haematoxylin and eosin staining of gWAT (J) and SAT (L) of miPEPfl/fl and aKO mice. Scale bar 100 μm. Quantification of the adipocyte size distribution for gWAT (K) and SAT (M) from the H&E staining, N = 5, p-value reported.