Figure 11.

Histological evaluation of chronic pancreatitis severity in T7D22N,K24R^hom× Spink1-KO^hetmice. C57BL/6N, T7D22N,K24R^hom, and T7D22N,K24R^hom × Spink1-KO^het mice were euthanized at 4 weeks, 6 weeks, 2 months, 4 months, and 6 months of age. (A) Representative hematoxylin-eosin stained pancreas sections from 4-week-old (left panels) and 6-month-old (right panels) mice. Scale bars are 100 μm. (B) Histology scoring for intact acinar cells. Individual values with the mean and standard deviation were plotted. The difference of means was analyzed by 1-way analysis of variance followed by Tukey’s post-hoc test.