Figure 7.

Intrapancreatic protease activity during disease progression after cerulein-induced acute pancreatitis. C57BL/6N and Spink1-KO^het mice were given 2 × 8 hourly injections of saline or cerulein on consecutive days and euthanized 3 days later. The pancreas was homogenized, and protease activities were measured as described in Methods. (A) Intrapancreatic trypsin activity. (B) Intrapancreatic chymotrypsin activity. Individual values with the mean and standard deviation were graphed. The difference of means was analyzed by 1-way analysis of variance with Tukey’s post-hoc test. The P values indicate pairwise comparisons between the saline and cerulein groups. The difference between the cerulein groups was not significant.