Table 1.

Recent studies that conducted affinity chromatography-based target identification of natural products.

No.	Natural product	Structure	Category	Bioactivity	Target protein	Reference
1	Artesunate		Quaternary ammonium salts	Regeneration of pancreatic β cell mass from α cells	Gephyrin	[4]
2	Arzanol		Terpenoids	Anti-inflammatory activity	Brain glycogen phosphorylase	[5]
3	Baicalein		Flavonoids	Elimination of liver tumor-initiating stem cell-like cells resistant to mTORC1 inhibition	SAR1B guanosine triphosphatase	[6]
4	20(S)-Protopanaxadiol		Saponins	Reduction of fatigue	CK-MM	[7]
5	IJ-5		Terpenoids	Anti-inflammatory activity	Ubiquitin-conjugating enzyme UbcH5	[8]
6	Sappanone A		Ketones	Anti-neuroinflammatory activity	IMPDH2	[10]
7	Celastrol		Terpenoids	Intervention of the progression of hepatocellular carcinoma	ROCK2	[11]
8	Ainsliadimer A		Terpenoids	Anticancer and anti-inflammatory activity	IKKβ	[12]
9	Pateamine A		Alkaloids	Inhibition of eukaryotic translation initiation	Eukaryotic initiation factor 4A	[13]
10	Adenanthin		Terpenoids	Induction of leukemic cell differentiation	Peroxiredoxins I and II	[14]

Note: The red-marked portion in the structure refers to the labeling binding site.