Table 10.

Recent studies that performed ITC-based target identification of natural products.

No.	Natural products	Category	Bioactivity		Target protein	Reference
1	Epigallocatechin gallate and tannic acid	Polyphenols	Reinforcement of the mucus barrier		Nucleophilic thiol groups of mucins	[84]
2	Thymoquinone	Isothiocyanates	Alleviation of Alzheimer's disease		Transferrin	[85]
3	Glycyrrhizin derivatives	Terpenoids	Suppression of cancer chemoresistance		Progesterone receptor membrane component 1	[86]
4	Valonea tannin	Polyphenols	Tyrosinase inhibition activity		Skin whitening properties	[87]
5	Coffee compounds	Alkaloids	Alleviation of depression and potentially type 2 diabetes		Monoamine oxidase A	[88]
		Polyphenols
6	Neoandrographolide	Terpenoids	Anticancer activity		Rab5	[89]
7	Piperine	Alkaloids	Alleviation of experimental allergic encephalomyelitis		Dihydroorotate dehydrogenase	[90]
8	Luteolin	Flavonoids	Antibacterial activity		HK853	[91]
9	Red clover isoflavones	Flavonoids	Inhibition of cancer cell metastasis		Actin	[92]
10	Constituents isolated from the root of R. crenulata	Flavonoids	Alleviation of Alzheimer's disease		Acetylcholinesterase	[93]
		Terpenoids
		Phenols