Table 2.

Recent studies that conducted ABPP-based target identification of natural products.

No.	Natural products	Structure	Category	Bioactivity	Target protein	Reference
1	Nimbolide		Terpenoids	Anticancer activity	E3 ubiquitin ligase RNF114	[21]
2	Parthenolide		Terpenoids	Anticancer activity	Ubiquitin carboxyl-terminal hydrolase 10 (USP10)	[22]
3	Dankastatin B		Terpenoids	Anticancer activity	Mitochondrial VDAC3	[23]
4	Salinipostin A		Cyclopeptide	Antimalarial activity	Essential α/β serine hydrolases	[25]
5	Illudin		Terpenoids	Anticancer activity	DNA modification and unselective protein binding	[26]
6	Withangulatin A		Alkaloids	Antitumor activity	phosphoglycerate dehydrogenase (PHGDH)	[27]
7	Piperlongumine		Alkaloids	Anticancer activity	GSTO1	[28]

Note: The red-marked portion in the structure refers to the labeling binding site.