Table 3.
Recent studies that performed PAL probe-based target identification of natural products.
| No. | Natural products | Structure | Category | Bioactivity | Target protein | Reference |
|---|---|---|---|---|---|---|
| 1 | Matrine |  |
Alkaloids | Anticancer activity | Annexin A2 | [30] |
| 2 | Coibamide A |  |
Cyclopeptide | Anticancer activity | Sec61 | [31] |
| 3 | Betulinic acid |  |
Terpenoids | Anticancer activity | Tropomyosin | [32] |
| 4 | Harringtonolide |  |
Cyclopeptide | Suppression of cancer cell migration | Receptor for activated C kinase 1 | [33] |
| 5 | Pseudolaric acid B |  |
Terpenoids | Anticancer activity | CD147 | [34] |
| 6 | Epothilone |  |
Macrolides | Alleviation of CNS injuries | The binding site on β-tubulin | [35] |
| 7 | Quercetin |  |
Flavonoids | Antitumor activity | HSP70, HSP90, RuvB-like 2 ATPases, and eukaryotic translation initiation factor 3 | [36] |
| 8 | Pladienolide |  |
Macrolides | Antitumor activity | Splicing factor SF3b | [37] |
Note: The red-marked portion in the structure refers to the labeling binding site.