Table 6.
Recent studies that conducted DARTS-based target identification of natural products.
| No. | Natural products | Category | Bioactivity | Target protein | Reference |
|---|---|---|---|---|---|
| 1 | Batzelladine A | Alkaloids | Suppression of lung cancer tumorigenesis | HSP90 | [47] |
| 2 | Andrographolide | Terpenoids | Alleviation of parkinsonism | DRP1 | [48] |
| 3 | Polyphyllin D | Saponins | NSCLC therapy | Distruption of HSC70–LAMP2A interaction | [49] |
| 4 | Ergolide | Terpenoids | Alleviation of inflammatory diseases | NLRP3 | [50] |
| 5 | Aconitine | Alkaloids | Cardiotoxicity | Cytosolic phospholipase A2 | [51] |
| 6 | Crellastatin A | Macrocyclic depsipeptides | Anticancer activity | PARP-1 | [52] |
| 7 | Cryptotanshinone | Diterpenoid quinone | Alleviation of keratinopathic ichthyosis | FKBP1A | [53] |
| 8 | Grape seed extract | Polyphenolic compounds | Anticancer activity | Endoplasmic reticulum stress response proteins | [54] |