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. 2024 Jun 29;10(13):e33917. doi: 10.1016/j.heliyon.2024.e33917

Table 7.

Recent studies that conducted TPP-based target identification of natural products.

No. Natural products Category Bioactivity Target protein Reference
1 Vioprolide A Cyclopeptide Anti-human acute lymphoblastic leukemia Nucleolar protein 14 [56]
2 Quinine Alkaloids Antimalarial activity Malarial parasite's intracellular purine nucleotide phosphorylase [57]
3 Rhodojaponin VI Saponins Alleviation of neuropathic pain N-ethylmaleimide-sensitive fusion protein [58]
4 Tutin Ketones Induction of epilepsy Calcineurin [59]
5 Alantolactone Terpenoids Inhibition of NSCLC AKR1C1 [60]
6 Kurarinone Flavonoids Attenuation of MPTP-mediated neuroinflammation Soluble epoxide hydrolase enzyme [61]
7 Arone Terpenoids Protection against neuroinflammation Histone-remodeling chaperone ASF1a [62]