Table 7.
Recent studies that conducted TPP-based target identification of natural products.
| No. | Natural products | Category | Bioactivity | Target protein | Reference |
|---|---|---|---|---|---|
| 1 | Vioprolide A | Cyclopeptide | Anti-human acute lymphoblastic leukemia | Nucleolar protein 14 | [56] |
| 2 | Quinine | Alkaloids | Antimalarial activity | Malarial parasite's intracellular purine nucleotide phosphorylase | [57] |
| 3 | Rhodojaponin VI | Saponins | Alleviation of neuropathic pain | N-ethylmaleimide-sensitive fusion protein | [58] |
| 4 | Tutin | Ketones | Induction of epilepsy | Calcineurin | [59] |
| 5 | Alantolactone | Terpenoids | Inhibition of NSCLC | AKR1C1 | [60] |
| 6 | Kurarinone | Flavonoids | Attenuation of MPTP-mediated neuroinflammation | Soluble epoxide hydrolase enzyme | [61] |
| 7 | Arone | Terpenoids | Protection against neuroinflammation | Histone-remodeling chaperone ASF1a | [62] |