Table 9.

Recent studies that conducted CETSA-based target identification of natural products.

No.	Natural products	Category	Bioactivity	Target protein	Reference
1	Usenamine A	Benzofuran derivatives	Alleviation of parkinsonism	Myosin-9	[68]
2	Paederosidic acid	Terpenoids	Suppression of osteoclast formation and neuropathic pain	P2Y14 receptor	[69]
3	Echinatin	Flavonoids	Inhibition of the hemolytic activity of methicillin-resistant S. aureus	Indirect binding to α-hemolysin	[70]
4	α-Asarone	Aromatic hydrocarbons	Alleviation of ischemic stroke	PI3K	[71]
5	Nitidine chloride	Alkaloids	Alleviation of multiple myeloma	ABCB6	[72]
6	Pentoxifylline	Methylxanthine derivatives	Alleviation of non-alcoholic fatty liver	Toll-like receptor 4 (TLR4)	[73]
7	Primary active constituents of the Xiang-lian pill (evodiamine, rutaecarpine, and stigmasterol)	Alkaloids	Anti-pancreatic cancer	PTGS2 and PTGS1	[74]
		Steroids
8	Toosendanin	Terpenoids	Anti-colorectal cancer	Shh	[75]
9	Glytabastan B	Flavonoids	Prevention and alleviation of rheumatoid arthritis	ERK2, JNK1 and class Ⅰ PI3K catalytic subunit p110	[76]
10	Tubocapsenolide A	Terpenoids	Therapeutic potential for osteosarcoma	Src homology 2 phosphatase 2	[77]
11	Primary constituents of Zuojin capsule	Alkaloids	Anti-colorectal cancer activity	CDKN1A, Bcl2, E2F1, PRKCB, MYC, CDK2, and MMP9	[78]
		Flavonoids
		Steroids
		Indole
12	Proanthocyanidin A1	Flavonoids	Amelioration of chemotherapy-induced thrombocytopenia	JAK2	[79]
13	Cucurbitacin B	Terpenoids	Anti-NSCLC activity	TLR4	[80]
14	Celastrol and gambogic acid	Terpenoids	Anti-breast cancer activity	ERα Y537S mutant	[81]
15	Shikonin	Terpenoids	Anti-triple-negative breast cancer activity	IMPDH2	[82]