Table 2. Antimycobacterial Activity of 5-FI against Pan-Sensitive H37Rv and Drug-Resistant Strains of Mtba.
| compound | MIC H37Rv (μM) | MIC PT2 (μM) | MIC PT12 (μM) | MIC PT20 (μM) | CC50b,c HepG2 (μM) | CC50b,c Vero (μM) |
|---|---|---|---|---|---|---|
| 5-FI | 4.7 | 4.7 | 4.7 | 4.7 | >20 | >20 |
| INH | 2.3 | 291.7 | 145.8 | 291.7 | ||
| RIF | 0.09 | >48.6 | >48.6 | >48.6 |
a
Viability of HepG2 and Vero strains in the presence of 5-FI after 72 h of exposure.
b
Concentration required to reduce cell viability by 50% (CC50).
c
Colorimetric assay based on 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide conversion and neutral red incorporation assay. INH, isoniazid. RIF, rifampin.