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| compound | aqueous solubilitya | metabolic stability | permeability | |||
|---|---|---|---|---|---|---|
| pH 1.2b (mM) | pH 7.4c (μM) | pH 9.1d (μM) | Clinte (mL/min/kg) | t1/2f (min) | PAMPA (10–6 cm/s) | |
| 5-FI | >550 | 3.5 | 2.2 | 9.0 | 144.2 | 2.4 |
Solubility determined after incubation at 25 °C for 4 h. 0.1 M.
HCl.
PBS.
0.1 M NH4HCO3.
Intrinsic clearance in the presence of rat liver microsomes.
Half-life.
