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| time (h) | open system (%) | closed system (%) |
|---|---|---|
| 0 | 100 ± 0.0 | 100 ± 0.0 |
| 1 | 97.5 ± 0.2 | 97.5 ± 0.1 |
| 2 | 95.4 ± 0.2 | 95.2 ± 0.0 |
| 4 | 83.4 ± 0.7 | 93.3 ± 0.1 |
| 6 | 88.9 ± 0.2 | 87.8 ± 0.0 |
| 24 | 89.1 ± 0.2 | 86.1 ± 0.0 |
| 48 | 85.5 ± 0.1 | 80.3 ± 0.1 |
