Table 9. Counting of CFUs and Determination of Spleen Mass in Animals in a Model of Tuberculosis in Micea.
groups | lungs | spleen weight |
---|---|---|
mean log10 CFU/mL ± SD | mean g ± SD | |
5-FI.HCl (10 μmol/kg) | 5.80 ± 0.20 | 0.58 ± 0.19 |
5-FI.HCl (30 μmol/kg) | 6.21 ± 0.32 | 0.55 ± 0.23 |
5-FI.HCl (100 μmol/kg) | 5.86 ± 0.67 | 0.62 ± 0.35 |
5-FI.HCl (200 μmol/kg) | 3.68 ± 0.45***, ### | 0.28 ± 0.06 |
INH (150 μmol/kg) | 2.43 ± 0.40***, ### | 0.23 ± 0.04 |
vehicle | 5.62 ± 0.60 | 0.49 ± 0.11 |
EC | 4.85 ± 0.32 | 0.34 ± 0.09 |
Data represent mean ± standard deviation. Statistical analysis was performed by one-way ANOVA followed by Tukey’s multiple comparisons test using GraphPad Prism 9.0.0 software. ***P < 0.001 compared to vehicle (0.9% NaCl) group. ###P < 0.001 compared to the EC group. N = 4–10 animals per group. 5-FI.HCl, 5-fluoroindole hydrochloride. INH, isoniazid. EC, early control.