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. 2024 Jul 16;9(30):32969–32979. doi: 10.1021/acsomega.4c03981

Table 9. Counting of CFUs and Determination of Spleen Mass in Animals in a Model of Tuberculosis in Micea.

groups lungs spleen weight
mean log10 CFU/mL ± SD mean g ± SD
5-FI.HCl (10 μmol/kg) 5.80 ± 0.20 0.58 ± 0.19
5-FI.HCl (30 μmol/kg) 6.21 ± 0.32 0.55 ± 0.23
5-FI.HCl (100 μmol/kg) 5.86 ± 0.67 0.62 ± 0.35
5-FI.HCl (200 μmol/kg) 3.68 ± 0.45***, ### 0.28 ± 0.06
INH (150 μmol/kg) 2.43 ± 0.40***, ### 0.23 ± 0.04
vehicle 5.62 ± 0.60 0.49 ± 0.11
EC 4.85 ± 0.32 0.34 ± 0.09
a

Data represent mean ± standard deviation. Statistical analysis was performed by one-way ANOVA followed by Tukey’s multiple comparisons test using GraphPad Prism 9.0.0 software. ***P < 0.001 compared to vehicle (0.9% NaCl) group. ###P < 0.001 compared to the EC group. N = 4–10 animals per group. 5-FI.HCl, 5-fluoroindole hydrochloride. INH, isoniazid. EC, early control.

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